Understanding how aging affects lymph nodes and immune function
Role of lymphatic endothelial cell NFkB signaling in adult lymph node homeostasis
This study is looking at how aging affects lymph nodes, which are important for our immune system, and it aims to find ways to improve immune responses in older adults by understanding the changes that happen in these nodes as we get older.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10741299 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms that maintain lymph nodes (LNs) as people age, focusing on how aging leads to LN atrophy and fibrosis, which can impair immune responses. The study will explore the role of lymphatic endothelial cells (LECs) and their signaling pathways, particularly the NFkB signaling, in regulating LN health. By using advanced 3D modeling and cell culture techniques, the research aims to uncover the molecular changes that occur in aged LNs and how these changes affect immune function. The ultimate goal is to identify potential therapies that could enhance immune responses in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related immune decline.
Not a fit: Patients who are younger than 21 or do not have age-related immune issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve immune function in elderly individuals.
How similar studies have performed: Previous research has shown promising results in understanding immune function and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Kataru, Raghu Prasad — Sloan-Kettering Inst Can Research
- Study coordinator: Kataru, Raghu Prasad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.