Understanding how aging affects HIV reservoirs
Official title: SIV reservoirs dynamics during aging
Funded at University of Nebraska Medical Center · NIH-11008218 · Data updated 2026-11-12
This study is looking at how aging affects the immune system and HIV reservoirs in older people living with HIV, using a type of monkey to help find better treatment options for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $300,000 |
| NIH project number | 1R21OD037751-01 |
| Project ID | NIH-11008218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older individuals living with HIV, particularly those who have been on antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who are not aged may not receive any benefit from this research.
What this research studies
This research investigates the dynamics of HIV reservoirs in older individuals living with HIV, focusing on how aging impacts immune cell composition and function. By studying SIV-infected, ART-treated rhesus macaques, the research aims to uncover the effects of age-related changes on HIV reservoirs, including DNA methylation patterns and T-cell functionality. The goal is to identify potential strategies for reducing these reservoirs, which could lead to improved treatment options for older patients living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for reducing HIV reservoirs in older patients, potentially paving the way for a cure.
How similar studies have gone: While research on HIV reservoirs has been conducted, this specific focus on aging and its effects on these reservoirs is relatively novel and has not been extensively studied.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Acharya, Arpan — University of Nebraska Medical Center
- Study coordinator: Acharya, Arpan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.