Understanding how aging affects bladder health.
Official title: Cellular and molecular mechanisms governing bladder aging.
Funded at Baylor College of Medicine · NIH-11170829 · Data updated 2026-11-12
This study is looking at how getting older affects the bladder and why it can lead to more urinary tract infections and incontinence, with the hope of finding new ways to help older adults keep their bladders healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 1R56AG084691-01A1 |
| Project ID | NIH-11170829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing bladder issues such as incontinence or recurrent urinary tract infections.
✕Less likely to help
Patients who are younger and do not have any bladder-related conditions may not benefit from this research.
What this research studies
This research investigates the cellular and molecular changes in the bladder that occur with aging, particularly how these changes increase the risk of urinary tract infections (UTIs) and incontinence. The study aims to identify specific molecular pathways and mechanisms that contribute to these age-related bladder conditions. By using mouse models, researchers will explore the role of ribosomal quality control and protein translation in maintaining bladder health. The findings could lead to the development of new therapies targeting these pathways to improve bladder function in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bladder health and reduce the incidence of UTIs and incontinence in older adults.
How similar studies have gone: Previous research has shown promising results in understanding cellular aging and its impact on various organ systems, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Mysorekar, Indira U — Baylor College of Medicine
- Study coordinator: Mysorekar, Indira U
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.