Understanding how ADAMTS10 affects glaucoma development
Official title: ADAMTS10 Regulation of Transforming Growth Factor Beta
Funded at Vanderbilt University Medical Center · NIH-11118547 · Data updated 2026-11-12
This study looks at how changes in a specific gene called ADAMTS10 might cause Primary Open Angle Glaucoma, which can lead to vision loss, by using mice to understand how these changes affect the eye; the findings could help improve treatments for people with glaucoma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $481,250 |
| NIH project number | 1R21EY037409-01 |
| Project ID | NIH-11118547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of glaucoma or those diagnosed with Primary Open Angle Glaucoma.
✕Less likely to help
Patients with glaucoma not linked to genetic mutations in ADAMTS10 may not benefit from this research.
What this research studies
This research investigates the role of the ADAMTS10 gene in causing Primary Open Angle Glaucoma (POAG), a condition that can lead to irreversible blindness. By studying mutations in ADAMTS10 found in specific dog breeds, researchers have created mouse models to explore how these mutations disrupt important signaling pathways in the retina. The study focuses on how these disruptions lead to the death of retinal cells and ultimately affect vision. Patients may benefit from insights gained about the genetic factors contributing to glaucoma and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for glaucoma, potentially preserving vision for affected individuals.
How similar studies have gone: Previous research has shown success in understanding genetic contributions to glaucoma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Kuchtey, John G — Vanderbilt University Medical Center
- Study coordinator: Kuchtey, John G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.