Understanding how ADAMTS10 affects glaucoma development
ADAMTS10 Regulation of Transforming Growth Factor Beta
This study looks at how changes in a specific gene called ADAMTS10 might cause Primary Open Angle Glaucoma, which can lead to vision loss, by using mice to understand how these changes affect the eye; the findings could help improve treatments for people with glaucoma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11118547 on NIH RePORTER |
What this research studies
This research investigates the role of the ADAMTS10 gene in causing Primary Open Angle Glaucoma (POAG), a condition that can lead to irreversible blindness. By studying mutations in ADAMTS10 found in specific dog breeds, researchers have created mouse models to explore how these mutations disrupt important signaling pathways in the retina. The study focuses on how these disruptions lead to the death of retinal cells and ultimately affect vision. Patients may benefit from insights gained about the genetic factors contributing to glaucoma and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of glaucoma or those diagnosed with Primary Open Angle Glaucoma.
Not a fit: Patients with glaucoma not linked to genetic mutations in ADAMTS10 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for glaucoma, potentially preserving vision for affected individuals.
How similar studies have performed: Previous research has shown success in understanding genetic contributions to glaucoma, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Kuchtey, John G — Vanderbilt University Medical Center
- Study coordinator: Kuchtey, John G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.