Understanding how a specific receptor affects methamphetamine addiction behaviors
Official title: Regulation of Methamphetamine-Induced Behaviors by the Neurotensin Receptor 1
Funded at University of Minnesota · NIH-11066813 · Data updated 2026-11-12
This study is looking at how a specific receptor in the brain might help improve behaviors linked to methamphetamine addiction, and it’s testing new compounds that could lead to better treatments with fewer side effects for people struggling with this issue.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $36,498 |
| NIH project number | 1F31DA062411-01 |
| Project ID | NIH-11066813 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of methamphetamine use or those diagnosed with methamphetamine use disorder.
✕Less likely to help
Patients who are not affected by methamphetamine addiction or those with other types of substance use disorders may not benefit from this research.
What this research studies
This research investigates the role of the neurotensin receptor 1 (NTSR1) in regulating behaviors associated with methamphetamine addiction. By using animal models, the study aims to explore how targeting this receptor can restore dopamine signaling disrupted by meth use. The researchers have developed a new class of small molecule NTSR1 ligands that selectively activate certain signaling pathways, potentially leading to effective treatments with fewer side effects. The goal is to better understand the mechanisms behind these ligands and their impact on addiction-related behaviors.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for individuals struggling with methamphetamine addiction.
How similar studies have gone: Previous research has shown promise in targeting similar receptors for addiction treatment, indicating potential for success in this novel approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Moore, Madelyn — University of Minnesota
- Study coordinator: Moore, Madelyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.