Understanding how a specific receptor affects methamphetamine addiction behaviors
Regulation of Methamphetamine-Induced Behaviors by the Neurotensin Receptor 1
This study is looking at how a specific receptor in the brain might help improve behaviors linked to methamphetamine addiction, and it’s testing new compounds that could lead to better treatments with fewer side effects for people struggling with this issue.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11066813 on NIH RePORTER |
What this research studies
This research investigates the role of the neurotensin receptor 1 (NTSR1) in regulating behaviors associated with methamphetamine addiction. By using animal models, the study aims to explore how targeting this receptor can restore dopamine signaling disrupted by meth use. The researchers have developed a new class of small molecule NTSR1 ligands that selectively activate certain signaling pathways, potentially leading to effective treatments with fewer side effects. The goal is to better understand the mechanisms behind these ligands and their impact on addiction-related behaviors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of methamphetamine use or those diagnosed with methamphetamine use disorder.
Not a fit: Patients who are not affected by methamphetamine addiction or those with other types of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for individuals struggling with methamphetamine addiction.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for addiction treatment, indicating potential for success in this novel approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Moore, Madelyn — University of Minnesota
- Study coordinator: Moore, Madelyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.