Understanding how a specific protein affects muscle loss
Official title: The role of Fbxl22 in the regulation of skeletal muscle mass
Funded at Oklahoma Medical Research Foundation · NIH-11088142 · Data updated 2026-11-12
This study is looking at a protein called Fbxl22 to see how it affects muscle loss and recovery, which could help find new treatments for people dealing with muscle wasting from chronic illnesses or inactivity.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $120,420 |
| NIH project number | 5K01AR077684-05 |
| Project ID | NIH-11088142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing muscle atrophy due to chronic illnesses or disuse.
✕Less likely to help
Patients with acute muscle injuries unrelated to chronic conditions may not benefit from this research.
What this research studies
This research investigates the role of a protein called Fbxl22 in the process of muscle atrophy, which can occur due to chronic diseases or disuse. The study aims to understand how Fbxl22 contributes to muscle loss and recovery by manipulating its expression in muscle tissue. Researchers will use advanced techniques to identify which proteins are targeted for degradation by Fbxl22, providing insights into muscle health and potential therapeutic approaches. Patients may benefit from findings that could lead to new treatments for muscle wasting conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse muscle atrophy in patients with chronic diseases.
How similar studies have gone: Previous research has shown that targeting E3 ubiquitin ligases can influence muscle mass, suggesting potential success for this approach.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Hughes, David C — Oklahoma Medical Research Foundation
- Study coordinator: Hughes, David C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.