Understanding how a specific protein affects memory in aging brains
Official title: Investigating HDAC3 phosphorylation as an epigenetic regulator of memory formation in the adult and aging brain
Funded at University of California-Irvine · NIH-10975030 · Data updated 2026-11-12
This study is looking at how a protein called HDAC3 affects memory as we get older, and it aims to find out how changes in this protein might influence memory and thinking skills in older adults, with hopes of discovering ways to help keep our minds sharp as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $45,518 |
| NIH project number | 5F31AG084268-02 |
| Project ID | NIH-10975030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who may be experiencing cognitive decline or memory issues.
✕Less likely to help
Patients under the age of 65 or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of HDAC3, a protein that regulates memory formation, in the aging brain. It aims to uncover how changes in the phosphorylation of HDAC3 may impact memory and cognitive function in older adults. By studying both young and aging mice, the researchers hope to identify the molecular mechanisms that contribute to memory decline and develop potential interventions to preserve cognitive abilities in older individuals.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating memory impairments associated with aging and neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of epigenetic factors in memory, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Rodriguez, Alyssa Crystal — University of California-Irvine
- Study coordinator: Rodriguez, Alyssa Crystal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.