Understanding how a specific protein affects lysosome function during aging
Official title: Unmasking p38 MAPK Functions in Lysosome Homeostasis during Development and Aging
Funded at Ut Southwestern Medical Center · NIH-10988328 · Data updated 2026-11-12
This study is looking at a protein called PMK-1 to see how it helps our cells keep their recycling centers, called lysosomes, working well as we get older, using tiny worms to learn more about how this process happens in different parts of the body.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $451,000 |
| NIH project number | 1R21AG086710-01A1 |
| Project ID | NIH-10988328 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may have age-related tissue integrity issues.
✕Less likely to help
Patients with acute conditions unrelated to aging or lysosomal function may not benefit from this research.
What this research studies
This research investigates the role of a protein called PMK-1 in the formation and function of lysosomes, which are essential for maintaining tissue integrity as we age. Using a model organism, C. elegans, the study aims to uncover how PMK-1 signals between different tissues to regulate lysosome regeneration and function. The researchers will employ various techniques, including genetic screens and biochemical analyses, to explore the interactions and specific roles of PMK-1 in different tissues and developmental stages. This work could provide insights into how lysosomes contribute to healthy aging and tissue maintenance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing tissue health and integrity in aging individuals.
How similar studies have gone: Previous studies have shown promising results in understanding lysosomal functions and their impact on aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Weaver, Benjamin P. — Ut Southwestern Medical Center
- Study coordinator: Weaver, Benjamin P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.