Understanding how a specific protein affects immune cell development
Official title: Mechanism of the transcription factor FoxP3 in regulatory T cell development
Funded at Boston Children's Hospital · NIH-10995329 · Data updated 2026-11-12
This study is looking at how a protein called FoxP3 helps shape special immune cells that keep our body's defenses in check and prevent autoimmune diseases, using advanced imaging techniques to better understand how it works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 6, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $772,604 |
| NIH project number | 5R01AI180137-02 |
| Project ID | NIH-10995329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune conditions or those at risk of developing such disorders.
✕Less likely to help
Patients with non-autoimmune related health issues may not receive any benefit from this research.
What this research studies
This research investigates the role of the FoxP3 protein in the development of regulatory T cells, which are crucial for maintaining immune balance and preventing autoimmune diseases. By examining the molecular mechanisms of FoxP3, the study aims to uncover how it influences the differentiation of these immune cells from their precursors. The researchers will utilize advanced techniques such as cryo-electron microscopy to visualize the structure of FoxP3 and its interactions with DNA, providing insights into its function in immune regulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for autoimmune diseases by enhancing our understanding of immune regulation.
How similar studies have gone: Previous research has shown promising results in understanding immune cell regulation, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Hur, Sun — Boston Children's Hospital
- Study coordinator: Hur, Sun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.