Understanding how a specific protein affects heart failure
Official title: Novel mitophagy regulatory mechanism in heart failure
Funded at Louisiana State Univ Hsc Shreveport · NIH-11110434 · Data updated 2026-11-12
This study is looking at a protein called Sigma 1 receptor to see how it helps keep heart cells healthy, especially when the heart is under stress, which could lead to new ways to understand and treat heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | June 7, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $660,348 |
| NIH project number | 5R01HL172970-02 |
| Project ID | NIH-11110434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure or those at risk of developing heart failure.
✕Less likely to help
Patients with heart conditions unrelated to the mechanisms being studied, such as congenital heart defects, may not benefit from this research.
What this research studies
This research investigates the role of a protein called Sigma 1 receptor in heart function and its potential impact on heart failure. The study focuses on how this protein helps maintain healthy heart cells by removing harmful components, especially under stress. By using specially designed mouse models, researchers aim to uncover the molecular mechanisms behind the protein's function in both normal and diseased hearts. This could lead to new insights into heart failure progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with heart failure.
How similar studies have gone: Previous research has shown that targeting similar molecular pathways can lead to significant advancements in understanding and treating heart conditions, indicating a promising avenue for this study.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Bhuiyan, Md. Shenuarin — Louisiana State Univ Hsc Shreveport
- Study coordinator: Bhuiyan, Md. Shenuarin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.