Understanding how a specific protein affects gut bacteria interactions during cholera infection
Official title: The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infection
Funded at University of Pennsylvania · NIH-11099712 · Data updated 2026-11-12
This study is looking at how a protein called TagA affects the way cholera bacteria interact with the good bacteria in our gut, which could help us understand why some people get sicker than others and lead to better, personalized treatments for cholera.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $754,348 |
| NIH project number | 5R01AI178908-03 |
| Project ID | NIH-11099712 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of cholera infection or have experienced cholera symptoms.
✕Less likely to help
Patients who have no history of cholera infection or are not at risk for cholera may not receive any benefit from this research.
What this research studies
This research investigates the role of a protein called TagA in how Vibrio cholerae interacts with the gut microbiota during cholera infection. By examining how this protein influences both the bacteria and the host's mucus layer, the study aims to uncover the mechanisms that lead to varying infection outcomes among individuals. The research employs advanced laboratory techniques, including tissue culture and mouse models, to explore these interactions in detail. Patients may benefit from insights that could lead to personalized treatments for cholera based on their unique gut microbiota.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for cholera that consider individual gut microbiota profiles.
How similar studies have gone: Other research has shown promise in understanding gut microbiota interactions with pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Zhu, Jun — University of Pennsylvania
- Study coordinator: Zhu, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.