Understanding how a specific protein affects gut bacteria interactions during cholera infection
The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infection
This study is looking at how a protein called TagA affects the way cholera bacteria interact with the good bacteria in our gut, which could help us understand why some people get sicker than others and lead to better, personalized treatments for cholera.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11099712 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called TagA in how Vibrio cholerae interacts with the gut microbiota during cholera infection. By examining how this protein influences both the bacteria and the host's mucus layer, the study aims to uncover the mechanisms that lead to varying infection outcomes among individuals. The research employs advanced laboratory techniques, including tissue culture and mouse models, to explore these interactions in detail. Patients may benefit from insights that could lead to personalized treatments for cholera based on their unique gut microbiota.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of cholera infection or have experienced cholera symptoms.
Not a fit: Patients who have no history of cholera infection or are not at risk for cholera may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for cholera that consider individual gut microbiota profiles.
How similar studies have performed: Other research has shown promise in understanding gut microbiota interactions with pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zhu, Jun — University of Pennsylvania
- Study coordinator: Zhu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.