Understanding how a specific protein affects brain signaling and stability.
Official title: Matrix Metalloproteinase 2 Controls Trans-Synaptic Homeostatic Plasticity in Drosophila
Funded at Georgetown University · NIH-10997633 · Data updated 2026-11-12
This study is looking at how a specific protein helps keep brain connections stable, which is important for good brain function, and it could provide helpful information for people dealing with conditions like Alzheimer's and autism.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $38,774 |
| NIH project number | 1F31NS139658-01 |
| Project ID | NIH-10997633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological disorders such as Alzheimer's disease or autism spectrum disorders.
✕Less likely to help
Patients with acute neurological injuries or those not affected by synaptic dysfunction may not receive benefit from this research.
What this research studies
This research investigates the role of Matrix Metalloproteinase 2 in controlling synaptic homeostasis, which is crucial for stable brain function. Using the Drosophila model, the study examines how changes in neurotransmitter release can maintain synaptic strength despite disruptions. By focusing on the neuromuscular junction, the research aims to uncover the molecular mechanisms behind homeostatic signaling that could be linked to various neurological disorders. Patients may benefit from insights gained about synaptic stability and its implications for conditions like Alzheimer's and autism.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological disorders by enhancing our understanding of synaptic stability.
How similar studies have gone: Previous research has shown success in understanding synaptic mechanisms in model organisms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Cai, Yimei — Georgetown University
- Study coordinator: Cai, Yimei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.