Understanding how a specific molecule affects Chlamydia growth and development
Official title: Characterizing the Function of Cyclic di-AMP on Chlamydial Growth and Differentiation
Funded at University of Nebraska Medical Center · NIH-11121088 · Data updated 2026-11-12
This study is looking at how a special molecule called cyclic di-AMP affects the growth and changes of Chlamydia trachomatis, which causes common sexually transmitted infections and can lead to blindness, with the hope of finding better treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | June 20, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $186,119 |
| NIH project number | 5R21AI180574-02 |
| Project ID | NIH-11121088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Chlamydia trachomatis infections or those at high risk for such infections.
✕Less likely to help
Patients who have other types of infections or those who are not infected with Chlamydia trachomatis may not benefit from this research.
What this research studies
This research investigates the role of cyclic di-AMP, a signaling molecule, in the growth and differentiation of Chlamydia trachomatis, a major cause of sexually transmitted infections and preventable blindness. By examining how this molecule influences the bacteria's ability to thrive and change forms, the research aims to uncover critical aspects of Chlamydia's biology that could lead to better treatment strategies. The approach involves laboratory experiments to analyze the bacteria's response to cyclic di-AMP and its impact on infection outcomes. Patients may benefit from improved understanding and potential new therapies targeting Chlamydia infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for Chlamydia infections, reducing the incidence of related health complications.
How similar studies have gone: Previous research has shown that understanding bacterial signaling pathways can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Ouellette, Scot P — University of Nebraska Medical Center
- Study coordinator: Ouellette, Scot P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.