Understanding how a specific gene causes hearing loss
Official title: Mechanisms of Mammalian Genetic Hearing Loss
Funded at Indiana University Indianapolis · NIH-11062395 · Data updated 2026-11-12
This study is looking at how a specific gene called TMPRSS3 might cause hearing loss by affecting the health of tiny hair cells in the inner ear, and it hopes to find ways to help prevent this condition for people who are dealing with hearing issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $590,122 |
| NIH project number | 5R01DC020574-03 |
| Project ID | NIH-11062395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic predispositions to hearing loss, particularly those with variants in the TMPRSS3 gene.
✕Less likely to help
Patients with hearing loss due to non-genetic factors or those without any known genetic variants may not benefit from this research.
What this research studies
This research investigates the role of the TMPRSS3 gene in causing hearing loss by focusing on how its protein affects hair cell survival in the inner ear. The study aims to uncover the biological mechanisms behind hair cell death, particularly how disruptions in tight junctions between cells lead to this condition. By examining the interactions of proteins and the cellular environment, the research seeks to provide insights into potential therapeutic targets for preventing hearing loss. Patients may benefit from a better understanding of genetic factors contributing to their hearing issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating genetic hearing loss.
How similar studies have gone: Other research has shown promising results in understanding genetic causes of hearing loss, making this approach both relevant and potentially impactful.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Nelson, Rick F — Indiana University Indianapolis
- Study coordinator: Nelson, Rick F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.