Understanding how a specific enzyme affects lung injury and respiratory distress
Examining the role of TRMT1 and tRNA methylation in acute lung injury and ARDS
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10857211
This study is looking at how a special enzyme called TRMT1 affects lung health during serious conditions like acute lung injury and ARDS, with the hope of finding new ways to improve treatments for these illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10857211 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific enzyme, TRMT1, and its impact on tRNA methylation in the context of acute lung injury and Acute Respiratory Distress Syndrome (ARDS). By examining how tRNA modifications respond to cellular stress and infection, the study aims to uncover new mechanisms that could lead to better treatments for ARDS. The research involves analyzing lung tissue samples and cellular responses to inflammatory stimuli to understand the enzyme's role in maintaining immune function and cell viability during critical illness.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who are experiencing or have a history of acute lung injury or ARDS.
Not a fit: Patients with chronic lung diseases or those not experiencing acute respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapeutic strategies for treating ARDS, potentially reducing mortality and improving patient outcomes.
How similar studies have performed: While the specific focus on TRMT1 and tRNA methylation in ARDS is relatively novel, previous studies have shown that targeting cellular stress responses can lead to significant advancements in treating critical illnesses.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONDINO, JAMES DAVID — OHIO STATE UNIVERSITY
- Study coordinator: LONDINO, JAMES DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Bacterial Infections