Understanding how a protein affects antibody development
Official title: The Role of UNG2 Degradation in Antibody Maturation
Funded at Wayne State University · NIH-11097200 · Data updated 2026-11-12
This study is looking at how a protein called mFAM72A helps improve the way our immune system makes antibodies, which are important for fighting off infections, and it could lead to better treatments for people with immune-related conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $228,200 |
| NIH project number | 5R21AI180183-02 |
| Project ID | NIH-11097200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions that affect antibody production or those who are immunocompromised.
✕Less likely to help
Patients with stable immune function and no history of antibody-related disorders may not receive direct benefits from this research.
What this research studies
This research investigates the role of a specific protein, mFAM72A, in the maturation of antibodies, which are crucial for the immune response. It focuses on how mFAM72A interacts with another protein, mUNG2, to regulate processes that enhance the effectiveness of antibodies. By examining the degradation of mUNG2, the research aims to uncover mechanisms that could improve antibody responses in patients. The study uses advanced molecular biology techniques to analyze these interactions in B lymphocytes, which are vital for producing antibodies.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing antibody responses, potentially benefiting patients with weakened immune systems or those undergoing treatments like chemotherapy.
How similar studies have gone: Other research has shown promising results in understanding antibody maturation processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Bhagwat, Ashok S — Wayne State University
- Study coordinator: Bhagwat, Ashok S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.