Understanding how a molecule called TRMT1 affects acute lung injury and ARDS
Examining the role of TRMT1 and tRNA methylation in acute lung injury and ARDS
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11130908
This project explores how a specific molecule called TRMT1 and its activity on other molecules called tRNAs might contribute to acute lung injury and ARDS, hoping to find new ways to help patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11130908 on ClinicalTrials.gov |
What this research studies
Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition that affects many patients in intensive care, and unfortunately, current treatments haven't significantly improved outcomes. This project aims to uncover new information about what causes ARDS by looking at a type of molecule called transfer RNA (tRNA), which is usually involved in making proteins but can also change how cells respond to stress. We are particularly interested in an enzyme called TRMT1, which modifies tRNAs and appears to be important for how the body fights infections and manages inflammation in the lungs. By understanding TRMT1's role, we hope to identify new targets for developing effective treatments for ARDS.
Who could benefit from this research
Good fit: This foundational research is for patients with acute lung injury or ARDS, as it seeks to understand the underlying biological mechanisms of their condition.
Not a fit: Patients without acute lung injury or ARDS would not directly benefit from this specific research, as it focuses on the mechanisms of these conditions.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of ARDS and potentially identify new targets for developing much-needed treatments for this severe lung condition.
How similar studies have performed: The role of tRNA biology in ARDS and critical care illnesses is largely unexplored, making this a novel approach to understanding the disease.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONDINO, JAMES DAVID — OHIO STATE UNIVERSITY
- Study coordinator: LONDINO, JAMES DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Bacterial Infections