Understanding genetic roots of hidradenitis suppurativa in African Americans
Official title: Establishing the contributions of monogenic etiologies to hidradenitis suppurativa pathogenesis
Funded at New York University School of Medicine · NIH-11171792 · Data updated 2026-11-12
A research team at NYU aims to find genetic factors that contribute to hidradenitis suppurativa, focusing on African American people who are disproportionately affected, to help guide future treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $651,389 |
| NIH project number | 5R01AR080796-03 |
| Project ID | NIH-11171792 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with hidradenitis suppurativa, with emphasis on African American individuals.
✕Less likely to help
People without HS or those not represented in the study population may not benefit.
What this research studies
This project looks at how genetic differences might drive inflammation in hidradenitis suppurativa. Researchers will use human genetic data to identify potential drug targets and improve how new therapies are developed. The study emphasizes inclusion of African American participants to address a gap in current knowledge. Results could help tailor treatments and speed up drug development for HS. The work could pave the way for personalized approaches based on genetic makeup.
Why it matters
Potential benefit: If successful, the findings could point to new treatment targets and improve drug development for HS, potentially leading to better symptom control for patients.
How similar studies have gone: Previous HS genetics studies are limited and have often excluded African Americans; this study expands the scope and may yield new insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Petukhova, Lynn — New York University School of Medicine
- Study coordinator: Petukhova, Lynn
Related research
Other NIH-funded projects on the same topics.
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Anti-CD38 immunotherapy for severe hidradenitis suppurativa
A new treatment using anti-CD38 therapy is being tested for people with severe hidradenitis suppurativa who have not responded to prior therapies.
-
Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
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Precision therapies for hidradenitis suppurativa using AI
A doctor-researcher team at UC San Francisco is using advanced computer methods to find personalized drug options to treat hidradenitis suppurativa.
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Injectable Hydrogel for HS: a localized therapy to ease painful skin disease
A new baricitinib hydrogel is being developed to deliver pain relief and reduce inflammation directly in hidradenitis suppurativa (HS) lesions, potentially lowering systemic side effects.
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Whole-genome sequencing to understand hidradenitis suppurativa in diverse groups
Researchers will study the genetic factors that contribute to hidradenitis suppurativa, especially in African American, Hispanic/Latino, and White patients, to better understand why some people are more affected.
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Understanding the Genes Behind Hidradenitis Suppurativa in teens and young adults
A study to find genetic factors that contribute to hidradenitis suppurativa (HS), a painful skin condition that often starts in adolescence and affects many Black individuals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.