Precision therapies for hidradenitis suppurativa using AI
Official title: Computational discovery of precision therapeutics for hidradenitis suppurativa
Funded at University of California, San Francisco · NIH-11436909 · Data updated 2026-11-12
A doctor-researcher team at UC San Francisco is using advanced computer methods to find personalized drug options to treat hidradenitis suppurativa.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $179,280 |
| NIH project number | 1K08AR088160-01 |
| Project ID | NIH-11436909 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with hidradenitis suppurativa or related inflammatory skin conditions whose molecular data may contribute to the analyses.
✕Less likely to help
Patients without HS or related inflammatory skin conditions may not directly benefit from this work.
What this research studies
This project uses computer models and large biological datasets to uncover how individual patients with hidradenitis suppurativa differ at the molecular level. The goal is to identify immunologic pathways specific to HS and to spot existing drugs that could be repurposed, potentially offering tailored treatments. The work combines public and new data, analyzes gene-expression patterns, and tests potential drug combinations in silico, with plans to validate promising candidates. If successful, this could accelerate the development of more effective, personalized therapies for HS patients.
Why it matters
Potential benefit: If successful, patients with HS could access more precise and effective treatment options tailored to their molecular profile.
How similar studies have gone: Previous in silico drug-repositioning efforts have shown potential in inflammatory diseases, but HS-specific precision therapy discovery remains exploratory.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Lee, Ernest Y. — University of California, San Francisco
- Study coordinator: Lee, Ernest Y.
Related research
Other NIH-funded projects on the same topics.
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Anti-CD38 immunotherapy for severe hidradenitis suppurativa
A new treatment using anti-CD38 therapy is being tested for people with severe hidradenitis suppurativa who have not responded to prior therapies.
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Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
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Injectable Hydrogel for HS: a localized therapy to ease painful skin disease
A new baricitinib hydrogel is being developed to deliver pain relief and reduce inflammation directly in hidradenitis suppurativa (HS) lesions, potentially lowering systemic side effects.
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Whole-genome sequencing to understand hidradenitis suppurativa in diverse groups
Researchers will study the genetic factors that contribute to hidradenitis suppurativa, especially in African American, Hispanic/Latino, and White patients, to better understand why some people are more affected.
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Understanding the Genes Behind Hidradenitis Suppurativa in teens and young adults
A study to find genetic factors that contribute to hidradenitis suppurativa (HS), a painful skin condition that often starts in adolescence and affects many Black individuals.
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Cortisol Synthesis and HS Tunnel Disease in 3D Skin Models
Aims to understand how cortisol production and signaling affect the painful tunnels in hidradenitis suppurativa using 3D skin models and patient tissue.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.