Understanding genetic changes linked to autism
Identifying tandem repeat expansion-mediated mechanisms of autism-risk genes
This research looks for specific genetic changes called tandem repeat expansions that might contribute to autism spectrum disorder.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project ID | NIH-11169851 on NIH RePORTER |
What this research studies
Many cases of autism spectrum disorder (ASD) don't have a clear genetic cause, even though we know genetics play a big role. This project focuses on a type of genetic change called tandem repeat expansions, which are stretches of DNA that repeat themselves and are often found in non-coding parts of our genes. We want to understand how these specific genetic changes might lead to ASD. By carefully studying these genetic variations, we hope to uncover new ways that genes contribute to autism.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals and families affected by autism spectrum disorder, especially those with an unknown genetic cause.
Not a fit: Patients seeking immediate new treatments or diagnostic tools will not directly benefit from this early-stage genetic discovery work.
Why it matters
Potential benefit: If successful, this work could help us better understand the underlying causes of autism, potentially leading to new ways to identify individuals at risk or develop targeted treatments in the future.
How similar studies have performed: While other large-scale studies have hinted at the role of these genetic changes in autism, this project aims to provide more rigorous and detailed understanding of their specific mechanisms.
Where this research is happening
Las Vegas, United States
- University of Nevada Las Vegas — Las Vegas, United States (Active)
Researchers
- Principal investigator: Sznajder, Lukasz Jakub — University of Nevada Las Vegas
- Study coordinator: Sznajder, Lukasz Jakub
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.