Understanding FABP5 in COPD Flares
Role of FABP5 in COPD Exacerbations
This research explores how a protein called FABP5 influences lung inflammation in people with chronic obstructive pulmonary disease, or COPD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-11145913 on NIH RePORTER |
What this research studies
We know that inflammation plays a big part in many lung conditions, especially COPD, where repeated infections can lead to severe flare-ups. Our bodies have special immune cells called macrophages in the lungs that are key to controlling this inflammation. These cells can either promote inflammation or help repair tissues, and their function is guided by their internal programming. This project aims to understand how a specific protein, FABP5, and its interaction with another protein, PPARγ, guide these macrophages to help resolve inflammation and prevent COPD flares. We are also looking at a genetic difference that might be linked to these flare-ups.
Who could benefit from this research
Good fit: Patients with chronic obstructive pulmonary disease (COPD), particularly those who experience frequent lung inflammation and exacerbations, are the focus of this research.
Not a fit: Individuals without COPD or chronic lung inflammation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target inflammation and prevent severe flare-ups in people living with COPD.
How similar studies have performed: While previous work has identified FABP5's role in macrophage function and a genetic link to COPD exacerbations, the critical role of this specific protein interaction and genetic variation for therapeutic targeting is currently unknown.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Gally, Fabienne — National Jewish Health
- Study coordinator: Gally, Fabienne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.