Understanding early mammalian embryo development
Official title: Decoding cell states and tissue morphogenesis in the early mammalian embryo
Funded at Sloan-Kettering Inst Can Research · NIH-10826387 · Data updated 2026-11-12
This study looks at how early mouse embryos develop by examining how two important types of cells form from a common starting point, helping us understand the basics of how embryos grow and develop.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $586,084 |
| NIH project number | 2R01HD094868-06A1 |
| Project ID | NIH-10826387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the genetic and developmental factors influencing early embryonic health, particularly those with a family history of birth defects.
✕Less likely to help
Patients who are not planning to conceive or who are not affected by genetic conditions related to embryonic development may not benefit from this research.
What this research studies
This research investigates the initial stages of mammalian embryo development, focusing on how two key cell lineages, the pluripotent epiblast and the extra-embryonic endoderm, arise from a common progenitor. Using mouse models, the study employs advanced techniques such as light microscopy and single-cell analysis to explore how these cells differentiate and organize into distinct tissue layers. The research aims to uncover the molecular and spatial dynamics that govern these processes, providing insights into embryonic development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of embryonic development and potentially lead to breakthroughs in preventing birth defects.
How similar studies have gone: Previous research has shown success in understanding embryonic development through similar methodologies, indicating a promising avenue for this investigation.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hadjantonakis, Anna-Katerina — Sloan-Kettering Inst Can Research
- Study coordinator: Hadjantonakis, Anna-Katerina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.