Understanding Down Syndrome from Shared Genetic Information
Official title: Curation and analysis of publicly available, molecular profiles from people with Down Syndrome
Funded at Brigham Young University · NIH-11076697 · Data updated 2026-11-12
This project carefully organizes and studies existing genetic information from individuals with Down Syndrome to better understand the condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $155,316 |
| NIH project number | 5R03HL168983-02 |
| Project ID | NIH-11076697 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project uses existing data, so direct patient participation is not required for this specific effort.
✕Less likely to help
Patients who do not have Down Syndrome or related conditions may not directly benefit from the specific findings of this data analysis.
What this research studies
This project gathers and cleans up genetic information that researchers have already collected from people with Down Syndrome and healthy individuals. By carefully organizing and standardizing this data, we can make sure it's accurate and ready for new discoveries. This helps us learn more about how genes work, why certain health conditions develop, and how we might predict future health outcomes. Our goal is to make it easier for scientists to use this valuable information to improve care for those with Down Syndrome.
Why it matters
Potential benefit: If successful, this work could lead to improved ways to diagnose and treat medical conditions associated with Down Syndrome, offering new insights into human health.
How similar studies have gone: While the approach of curating and analyzing existing public data is established, this specific, large-scale reprocessing of Down Syndrome molecular profiles is a focused and novel effort.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Piccolo, Stephen — Brigham Young University
- Study coordinator: Piccolo, Stephen
Related research
Other NIH-funded projects on the same topics.
-
Exploring how Down syndrome affects optic nerve health in kids
A study using a mouse model to understand why optic nerve problems are common in children with Down syndrome and how to prevent them.
-
Executive Function Enhancement for Young Children with Down Syndrome
A caregiver-guided program for kids with Down syndrome aged up to 11 to strengthen their thinking skills during early childhood.
-
Silencing an Extra Chromosome to Help Down Syndrome and Related Conditions
A patient-friendly plan to use a gene-based approach to quiet an extra chromosome in cells and a mouse model to reduce disease-related effects in Down syndrome and other chromosomal imbalance disorders.
-
Infant Down Syndrome Brain and Behavior Study
A study of infants with Down syndrome to collect brain imaging and developmental data, creating a large, shared resource to understand how autism and other factors relate to development.
-
DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s
A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.
-
Immune and NGF factors in Alzheimer’s for adults with Down syndrome
This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.