Understanding different types of POTS to tailor treatments
Official title: Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
Funded at Ut Southwestern Medical Center · NIH-11378317 · Data updated 2026-11-12
A research project is studying why people with POTS have different symptoms and how to personalize exercise-based treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,733,870 |
| NIH project number | 5R01HL166272-04 |
| Project ID | NIH-11378317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with POTS who are eligible for exercise-based interventions and willing to undergo comprehensive assessments.
✕Less likely to help
Patients who do not meet the study criteria or are unable to participate in the required tests and follow-up may not benefit.
What this research studies
This project will enroll a diverse group of people with Postural Orthostatic Tachycardia Syndrome (POTS) and carefully measure symptoms, blood markers, heart structure, and how muscles respond to exercise. By comparing these data, researchers aim to map distinct subtypes of POTS and their underlying biology. The goal is to help clinicians choose the most effective, individualized treatment plans for each patient who has POTS.
Why it matters
Potential benefit: If successful, patients could receive more personalized and effective management of POTS, improving symptoms and daily functioning.
How similar studies have gone: Previous work showed exercise helps some POTS patients, but this study seeks to define subtypes and tailor therapy.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Vernino, Steven a — Ut Southwestern Medical Center
- Study coordinator: Vernino, Steven a
Related research
Other NIH-funded projects on the same topics.
-
Map heart tissue to guide VT ablation with AI help
A patient-oriented project aims to use AI-based mapping to better identify abnormal heart tissue responsible for ventricular tachycardia and guide safer, faster ablation.
-
Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
-
Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
-
Novel gene therapy tools to prevent dangerous heart rhythms
A small grant supports testing gene-therapy methods to stop ventricular tachycardia after a heart attack, with the goal of helping people at risk of sudden heart rhythm problems.
-
GIP and blood pooling in the gut: a potential driver of POTS symptoms
This NIH grant studies how a glucose-driven hormone affects blood flow and heart rate in adults with Postural Tachycardia Syndrome to explain why meals can worsen symptoms.
-
Radiation-guided ablation for ventricular tachycardia
This project tests a noninvasive radiation approach to ablate heart tissue in people with dangerous ventricular tachycardia to reduce the need for invasive procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.