Radiation-guided ablation for ventricular tachycardia
Official title: Radiation Guided Ablation for Ventricular Tachycardia
Funded at Utah State Higher Education System--University of Utah · NIH-11336875 · Data updated 2026-11-12
This project tests a noninvasive radiation approach to ablate heart tissue in people with dangerous ventricular tachycardia to reduce the need for invasive procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 10, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $737,907 |
| NIH project number | 5R01HL174056-03 |
| Project ID | NIH-11336875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with ventricular tachycardia who are candidates for ablation and may benefit from noninvasive radiation-based therapy.
✕Less likely to help
Patients whose VT is not due to tissue areas addressable by radiation or who cannot tolerate radiation therapy.
What this research studies
Ventricular tachycardia is a dangerous heart rhythm that currently often requires invasive catheter ablation under anesthesia. This grant aims to use targeted radiation to noninvasively destroy the problematic heart tissue and maps infrastructure from imaging, electrophysiology, and radiation oncology to optimize the approach. Researchers will explore how radiation changes heart tissue over time, how quickly effects appear, and how to best identify target sites without surgery. If successful, this could lead to faster procedures with potentially fewer complications for patients with weakened heart function.
Why it matters
Potential benefit: Patients could experience safer, noninvasive treatment options for ventricular tachycardia with potentially shorter procedures and fewer complications.
How similar studies have gone: Early, limited experiences have shown promise for radiation-based ablation but large-scale and long-term data are still needed.
Where this research is happening
-
Utah State Higher Education System--University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Ranjan, Ravi — Utah State Higher Education System--University of Utah
- Study coordinator: Ranjan, Ravi
Related research
Other NIH-funded projects on the same topics.
-
Map heart tissue to guide VT ablation with AI help
A patient-oriented project aims to use AI-based mapping to better identify abnormal heart tissue responsible for ventricular tachycardia and guide safer, faster ablation.
-
Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
-
Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
-
Novel gene therapy tools to prevent dangerous heart rhythms
A small grant supports testing gene-therapy methods to stop ventricular tachycardia after a heart attack, with the goal of helping people at risk of sudden heart rhythm problems.
-
Low-Field MRI–Guided Robotic Catheter System for VT Ablation
A research project is testing a new low-field MRI–guided robotic catheter to improve treatment of ventricular tachycardia for patients with abnormal heart structure.
-
Wideband 3D heart imaging to guide VT ablation
A new imaging approach uses 3D wideband heart scans to plan and guide ablation for ventricular tachycardia patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.