Understanding diet and gut microbiota in eosinophil residency and inflammatory disease
Official title: Understanding diet-microbiota interactions in small intestine eosinophil tissue residency during homeostasis and eosinophilic granulomatosis with polyangiitis (EGPA)
Funded at University of Colorado Denver · NIH-11393934 · Data updated 2026-11-12
A physician-scientist-in-training will study how what we eat and our gut microbes influence immune cells in the small intestine, aiming to improve understanding of inflammatory diseases.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $173,556 |
| NIH project number | 5K08AR084069-03 |
| Project ID | NIH-11393934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with eosinophilic-type inflammatory conditions or related mucosal inflammatory diseases who may benefit from future translational work.
✕Less likely to help
Healthy individuals without inflammatory gut conditions may not directly benefit from this training-focused grant.
What this research studies
This five-year program trains Dr. Korn to become an independent physician-scientist focused on mucosal immunology and inflammatory diseases. She will learn about gut physiology, the microbiome, and how environmental factors drive inflammation, using a mouse model of eosinophilic disease to explore mechanisms. The work is mentored by a leader in inflammation biology and supported by Yale and the University of Colorado Denver. The goal is to uncover how nutrients and microbiota influence eosinophil residency in the small intestine during health and disease. The grant supports career development, research training, and mentorship to translate basic findings toward inflammatory disease therapies.
Why it matters
Potential benefit: This research could illuminate how diet and gut microbes shape intestinal immunity, potentially guiding new strategies to treat eosinophilic diseases.
How similar studies have gone: Prior work in mucosal immunology and microbiome research has yielded insightful links between diet, microbiota, and inflammation, supporting the potential of this approach.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Korn, Lisa Lenore — University of Colorado Denver
- Study coordinator: Korn, Lisa Lenore
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.