How gut bacteria metabolites affect your immune system and allergies
Official title: Microbiota-derived metabolites and the regulation of host immunity and inflammation
Funded at Weill Medical Coll of Cornell Univ · NIH-11520822 · Data updated 2026-11-12
This project looks at how substances made by the gut microbiome influence the body’s immune responses to allergic diseases and intestinal infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 14, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $141,266 |
| NIH project number | 3R01AI172027-05S1 |
| Project ID | NIH-11520822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with allergic diseases or intestinal infections who are able to provide samples or participate in related studies may be eligible.
✕Less likely to help
Individuals without allergic disease or gut-related conditions may not directly benefit from this study.
What this research studies
If you have allergic disease or are affected by intestinal parasites, this research explores the tiny molecules produced by gut microbes and how they shape immune cells. The study uses laboratory analyses and animal or human samples to uncover the mechanisms by which diet, microbiota, and these metabolites modulate type 2 immunity and inflammation. The findings could point to new ways to prevent or treat allergies and infections by targeting microbiome signals. The work is led by Weill Cornell Medicine researchers and aims to translate basic knowledge into strategies for better allergy and infection control.
Why it matters
Potential benefit: Understanding these mechanisms could lead to new dietary or microbiome-based approaches to reduce allergy symptoms and improve resistance to intestinal infections.
How similar studies have gone: Previous studies indicate microbiome-derived metabolites can influence immune responses, supporting the potential relevance of this approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Artis, David — Weill Medical Coll of Cornell Univ
- Study coordinator: Artis, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.