Understanding brain function changes in people with HIV
Official title: Coupling of Inflammasome Cascades and Aberrant Neural Oscillatory Dynamics in NeuroHIV
Funded at Father Flanagan's Boys' Home · NIH-11053565 · Data updated 2026-11-12
This study is looking at how HIV impacts thinking and memory in people living with the virus, and it aims to find ways to help improve brain health by understanding the underlying causes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Father Flanagan's Boys' Home NIH-funded |
| Lab location | 1 site (Boys Town, United States) |
| Project start | April 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $559,846 |
| NIH project number | 5R01DA059877-02 |
| Project ID | NIH-11053565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are living with HIV and experiencing cognitive impairments.
✕Less likely to help
Patients who are not living with HIV or who do not exhibit cognitive impairments may not benefit from this research.
What this research studies
This research investigates how HIV affects brain function, particularly focusing on cognitive impairments that are common among individuals living with HIV. The study aims to explore the molecular pathways and inflammasome activation that contribute to these cognitive issues, using advanced neuroimaging techniques and biomarkers. By identifying the specific brain circuits involved, the research seeks to develop potential therapeutic strategies to improve cognitive health in people with HIV.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for individuals living with HIV.
How similar studies have gone: Previous research has shown promise in understanding cognitive impairments in HIV, but this specific approach focusing on inflammasome pathways is relatively novel.
Where this research is happening
-
Father Flanagan's Boys' Home
Boys Town, United States Active
Researchers
- Principal investigator: Wilson, Tony W — Father Flanagan's Boys' Home
- Study coordinator: Wilson, Tony W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.