Understanding brain connectivity changes in Alzheimer's disease using advanced imaging and protein analysis
Official title: Incorporating Spatial Proteomics to Understand the Basis of Hyper and Hypoconnectivity in mouse models of AD
Funded at Baylor College of Medicine · NIH-11116981 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects connections in the brain by using advanced imaging and protein analysis in mice, hoping to uncover how certain proteins might influence the disease's progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $766,795 |
| NIH project number | 5R01AG081192-02 |
| Project ID | NIH-11116981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a diagnosis of Alzheimer's disease or those at risk for developing the condition.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the changes in brain connectivity associated with Alzheimer's disease by combining high-resolution MRI imaging with spatial proteomics in mouse models. The study aims to identify how different proteins are expressed in areas of the brain that show either increased or decreased connectivity. By utilizing machine learning, researchers will analyze these data to better understand the underlying mechanisms of Alzheimer's disease. This approach could lead to insights into the roles of specific proteins in the progression of the disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for Alzheimer's disease, potentially improving treatment options for patients.
How similar studies have gone: Previous research has shown promise in using imaging and proteomic techniques to study Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Pautler, Robia G — Baylor College of Medicine
- Study coordinator: Pautler, Robia G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.