Understanding aging-related changes in bone cells
Official title: Characterization of senescent cell populations in skeletal aging
Funded at Mayo Clinic Rochester · NIH-11141239 · Data updated 2026-11-12
This study is looking at how certain bone cells change as we age and how these changes might lead to bone loss and other health problems, with the hope of finding new ways to help older adults stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $510,415 |
| NIH project number | 5R01AG086085-02 |
| Project ID | NIH-11141239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related bone loss or related health issues.
✕Less likely to help
Patients who are younger and do not have age-related bone loss or associated conditions may not benefit from this research.
What this research studies
This research investigates how certain cells in the bone contribute to age-related bone loss and other health issues associated with aging. By analyzing specific markers and characteristics of these cells, the study aims to identify different types of senescent cells that may play a role in these conditions. The researchers will use advanced techniques to perform detailed analyses of these cells in mice, which could lead to new strategies for preventing bone loss and improving overall health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent age-related bone loss and improve health outcomes for older adults.
How similar studies have gone: Previous research has shown promising results in understanding cellular senescence and its impact on aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Khosla, Sundeep — Mayo Clinic Rochester
- Study coordinator: Khosla, Sundeep
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.