Molecular basis for S1PR1 blockers in migraine and TMD pain
Official title: Molecular basis for functional S1PR1 antagonists in the treatment of comorbid migraine and temporomandibular disorders
Funded at University of Maryland Baltimore · NIH-11398121 · Data updated 2026-11-12
A basic science project to explore how blocking S1PR1 could help people who have both migraine and temporomandibular disorders by studying pain pathways in animal models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $573,560 |
| NIH project number | 5R01NS138127-03 |
| Project ID | NIH-11398121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with comorbid migraine and temporomandibular disorders in whom future trials of S1PR1-targeted therapies could be considered.
✕Less likely to help
Patients without migraine/TMD comorbidity or those not likely to contribute to translational research may not directly benefit.
What this research studies
This grant focuses on understanding how S1PR1 signaling contributes to pain in migraine and TMD using animal models. Researchers will examine molecular pathways, inflammatory signals, and neuronal communication to see how S1PR1 influences pain in the trigeminal system. The work aims to identify potential new treatments that could translate into safer, more effective options for patients with these combined conditions.
Why it matters
Potential benefit: If successful, the research could lead to new S1PR1-based therapies to reduce pain for people who suffer from both migraine and TMD.
How similar studies have gone: Prior work shows S1PR1 involvement in spinal pain models, supporting potential translation to trigeminal pain.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Akerman, Simon — University of Maryland Baltimore
- Study coordinator: Akerman, Simon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.