Ultrasound method to safely treat brain bleeds without open surgery
Official title: Novel Ultrasonic Technique for the Treatment of Hemorrhagic Stroke
Funded at University of Michigan at Ann Arbor · NIH-11379522 · Data updated 2026-11-12
A new ultrasound-based technique aims to liquefy and drain intracerebral hemorrhage through the skull in a minimally invasive way.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 30, 2018 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $668,221 |
| NIH project number | 5U01NS108042-07 |
| Project ID | NIH-11379522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with intracerebral hemorrhage who could be candidates for minimally invasive clot removal.
✕Less likely to help
Patients with hemorrhages not suitable for ultrasound-based treatment or with contraindications to catheter drainage.
What this research studies
This project continues work on NaviTH, a neuronavigation-guided, transcranial histotripsy approach to treat bleeding inside the brain. By using focused ultrasound from outside the head, the clot is liquefied quickly so it can be removed with a small catheter, aiming to reduce brain damage and improve recovery. The study seeks to advance safe, less invasive options for intracerebral hemorrhage compared with traditional craniotomy or thrombolytics. Researchers will test system feasibility, safety, and potential clinical benefit in patients who have bleeding in the brain. The ultimate goal is to offer a faster, gentler treatment that preserves surrounding brain tissue while clearing the clot.
Why it matters
Potential benefit: If successful, patients with brain hemorrhages could recover with less invasive procedures and better outcomes.
How similar studies have gone: Preliminary results from prior work showed feasibility and safety, with ongoing efforts to demonstrate clinical benefit.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Pandey, Aditya S — University of Michigan at Ann Arbor
- Study coordinator: Pandey, Aditya S
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Early clotting-factor treatment for sudden brain bleed
This research gives a clotting medicine called rFVIIa very soon after a sudden brain bleed to see whether people with intracerebral hemorrhage do better than with standard care alone.
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Early Factor VIIa treatment for bleeding stroke
This research compares early intravenous recombinant Factor VIIa plus usual care with usual care alone for people who have a sudden brain bleed (intracerebral hemorrhage) to try to improve recovery.
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Ultrasound method to break up and drain brain clots from bleeding strokes
Using focused ultrasound through the skull to liquefy and drain blood clots for people with intracerebral hemorrhage (bleeding stroke).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.