Ultrasensitive detection of circulating DNA methylation to guide head and neck cancer prognosis

Who could benefit from this research

What this research studies

This project aims to create a clinical cohort to study non-invasive DNA methylation markers in circulating DNA and immune cells from blood in patients with head and neck squamous cell carcinoma. By using ultrasensitive detection methods, it seeks to improve prognostic accuracy and help tailor treatments, including immunotherapy or de-escalation for lower-risk patients. The study will combine molecular testing with clinical follow-up to see how well these markers predict survival and recurrence. Results could lead to more personalized care and better survival for patients with HPV-negative tumors.

Why it matters

Where this research is happening

• H. Lee Moffitt Cancer Ctr & Res Inst
  Tampa, United States Active

Researchers

• Principal investigator: Chung, Christine H — H. Lee Moffitt Cancer Ctr & Res Inst
• Study coordinator: Chung, Christine H

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.