Translatomic changes in aging heart: ribosome players
Official title: Translatomic Changes During Cardiac Aging: Ribosomal Protein and Initiation Factor Interactions
Funded at Montana State University - Bozeman · NIH-11441715 · Data updated 2026-11-12
A study to understand how aging changes the heart at the molecular level by looking at ribosomes and initiation factors in heart cells.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $398,750 |
| NIH project number | 1R21AG104135-01 |
| Project ID | NIH-11441715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for cardiovascular disease or aging-related heart changes may benefit from future translational applications.
✕Less likely to help
If heart aging mechanisms differ from those studied in this project, there may be limited direct benefit.
What this research studies
This project will examine how aging alters the heart’s protein-making machinery, focusing on ribosomal proteins and initiation factors. Researchers will study how changes in ribosome composition affect which proteins are made in heart tissue as people age. The team will use model systems and human-relevant data to map shifts in the cardiac translatome and relate them to aging-related heart problems. The goal is to identify targets that could help preserve heart function in older adults.
Why it matters
Potential benefit: If successful, this work could reveal new targets to slow heart aging and reduce age-related cardiovascular disease.
How similar studies have gone: Previous work shows ribosome changes can influence aging, with some model-system findings supporting the approach; human relevance is being explored.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: Schroeder, Analyne M. — Montana State University - Bozeman
- Study coordinator: Schroeder, Analyne M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.