Transdiagnostic Sleep and Circadian Treatment to Help Depression in Older Adults at Risk of Suicide

Who could benefit from this research

What this research studies

This project tests a behavioral approach called TranS-C to stabilize sleep and daily rhythms in adults 21 and older with moderate-to-severe depression and active suicide risk. The study builds on pilot findings and compares TranS-C to standard care to see if better sleep patterns lead to more durable improvement in depression. It includes adults in hospital-like or clinical settings and tracks depression severity, suicidal thoughts, and any suicidal behaviors for six months after treatment. The trial uses rigorous, double-blind methods and multi-site participation to ensure reliable results.

Why it matters

Where this research is happening

• University of Pittsburgh at Pittsburgh
  Pittsburgh, United States Active

Researchers

• Principal investigator: Smagula, Stephen F — University of Pittsburgh at Pittsburgh
• Study coordinator: Smagula, Stephen F

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.