Cognitive-behavioral therapy then exercise to lower type 2 diabetes risk in teenage girls

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

NIH-funded research Colorado State University · NIH-11324577

Teen girls at risk for type 2 diabetes will try short-term talking therapy first, then structured exercise, to help lift mood, increase activity, and lower diabetes risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColorado State University NIH-funded
Lab location1 site (Fort Collins, United States)
Project IDNIH-11324577 on NIH RePORTER

What this research studies

This project offers teen girls at high risk for type 2 diabetes a sequence of treatments: first short-term cognitive-behavioral therapy (CBT) to reduce depression, followed by a supervised exercise training program to improve fitness. Researchers will measure insulin resistance, physical activity, cardiorespiratory fitness, mood symptoms, and how well participants stick with the exercise plan before and after the interventions. The team focuses especially on females from historically disadvantaged racial and ethnic groups and will compare outcomes to see if treating mood first improves engagement with exercise and metabolic health. Sessions are likely delivered in person and include counseling and guided workouts with monitoring.

Who could benefit from this research

Good fit: Girls roughly ages 12–19 who are overweight or obese, at high risk for type 2 diabetes, and who have depressive symptoms are the ideal participants.

Not a fit: Boys, adults, teens already diagnosed with type 2 diabetes, or teens without mood symptoms or who cannot take part in therapy or supervised exercise are unlikely to benefit from joining this project.

Why it matters

Potential benefit: If successful, this approach could lower insulin resistance and future diabetes risk while improving mood and exercise adherence in at-risk teen girls.

How similar studies have performed: Exercise alone has shown short-term metabolic benefits in adolescents but limited long-term effects, and using CBT first to boost exercise adherence is a newer approach with some supportive adult data but limited pediatric evidence.

Where this research is happening

Fort Collins, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Adult-Onset Diabetes Mellitus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.