Testing a new cycling exercise program to help stroke recovery
Official title: The I-SCORE (Intensive Stroke Cycling for Optimal Recovery and Economic value) Trial
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11060958 · Data updated 2026-11-12
This study is exploring a new way to help people recover from strokes by using special cycling exercises that combine support and aerobic activity, aiming to improve movement in their arms and legs better than regular rehab methods.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $626,754 |
| NIH project number | 5R01HD114650-02 |
| Project ID | NIH-11060958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke within the subacute phase of recovery.
✕Less likely to help
Patients who are in the chronic phase of stroke recovery or those with severe comorbidities may not benefit from this research.
What this research studies
This research investigates a novel approach to stroke rehabilitation by using forced aerobic exercise (FE) cycling to enhance motor recovery in stroke survivors. The program aims to combine mechanical assistance with aerobic exercise to help patients achieve better outcomes in their upper and lower extremity functions. By rigorously testing this method in individuals who have recently experienced a stroke, the study seeks to determine its effectiveness and cost-efficiency compared to traditional rehabilitation methods. Patients will engage in cycling sessions that are designed to push their limits while still being manageable, potentially leading to improved recovery rates.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery outcomes for stroke survivors, reducing long-term disabilities.
How similar studies have gone: Previous studies have shown promising results with forced aerobic exercise in animal models, suggesting potential success in human applications.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Linder, Susan Marie — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Linder, Susan Marie
Related research
Other NIH-funded projects on the same topics.
-
Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
-
LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
-
BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.