Testing a new cycling exercise program to help stroke recovery

The I-SCORE (Intensive Stroke Cycling for Optimal Recovery and Economic value) Trial

NIH-funded research Cleveland Clinic Lerner Com-Cwru · NIH-11060958

This study is exploring a new way to help people recover from strokes by using special cycling exercises that combine support and aerobic activity, aiming to improve movement in their arms and legs better than regular rehab methods.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionCleveland Clinic Lerner Com-Cwru NIH-funded
Lab location1 site (Cleveland, United States)
Project IDNIH-11060958 on NIH RePORTER

What this research studies

This research investigates a novel approach to stroke rehabilitation by using forced aerobic exercise (FE) cycling to enhance motor recovery in stroke survivors. The program aims to combine mechanical assistance with aerobic exercise to help patients achieve better outcomes in their upper and lower extremity functions. By rigorously testing this method in individuals who have recently experienced a stroke, the study seeks to determine its effectiveness and cost-efficiency compared to traditional rehabilitation methods. Patients will engage in cycling sessions that are designed to push their limits while still being manageable, potentially leading to improved recovery rates.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have experienced a stroke within the subacute phase of recovery.

Not a fit: Patients who are in the chronic phase of stroke recovery or those with severe comorbidities may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve recovery outcomes for stroke survivors, reducing long-term disabilities.

How similar studies have performed: Previous studies have shown promising results with forced aerobic exercise in animal models, suggesting potential success in human applications.

Where this research is happening

Cleveland, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired brain injury
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.