Targeting new ways to control opioid effects
Official title: Pharmacological targeting of nascent modulators of opioid signaling
Funded at University of Florida · NIH-11018935 · Data updated 2026-11-12
This study is looking for new ways to make pain relief from opioids safer, so people can manage their pain without the worry of becoming addicted.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $772,800 |
| NIH project number | 1R01DA061771-01 |
| Project ID | NIH-11018935 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who require pain management and are at risk of developing opioid dependence.
✕Less likely to help
Patients who do not require pain relief or who are not affected by opioid addiction may not benefit from this research.
What this research studies
This research investigates how to modify the effects of opioids, which are commonly used for pain relief but can also lead to addiction and other negative outcomes. The team aims to identify new modulators that can change how opioid receptors in the brain work, potentially reducing dependence while maintaining pain relief. They will use advanced genetic and chemical biology techniques to discover and test these new compounds. By understanding and altering the signaling pathways of opioid receptors, the research hopes to improve treatment options for patients who need pain management without the risk of addiction.
Why it matters
Potential benefit: If successful, this research could lead to safer pain management options that minimize the risk of addiction and overdose.
How similar studies have gone: Previous research has shown promise in targeting opioid receptor signaling, suggesting that this approach could lead to significant advancements in pain management.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Martemyanov, Kirill a. — University of Florida
- Study coordinator: Martemyanov, Kirill a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.