Targeting CCL20 and CCR6 in Colorectal Cancer
Official title: Targeting CCL20-CCR6 Interactions in Colorectal Cancer
Funded at VA Boston Health Care System · NIH-11310757 · Data updated 2026-11-12
A patient-focused look at a study exploring whether blocking a specific chemical signal (CCL20-CCR6) can slow colorectal cancer growth and spread.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2018 |
| Project end | March 31, 2029 |
| Funding year | 2027 |
| NIH project number | 5I01BX003771-06 |
| Project ID | NIH-11310757 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with colorectal cancer who are eligible for ongoing or additional cancer therapies and who can participate in research evaluations.
✕Less likely to help
Patients whose cancer biology does not rely on the CCL20-CCR6 pathway or who cannot participate in the trial due to health or safety reasons may not benefit.
What this research studies
This research tests a new approach in colorectal cancer by interrupting the CCL20-CCR6 communication that may help tumors grow. It builds on lab and animal data suggesting that stopping this signal could reduce tumor cell movement, growth, and invasive behavior. The goal is to learn how this strategy might fit with existing treatments in patients whose health allows more intensive therapy. The study is conducted at VA Boston Health Care System, led by Dr. Jason Samuel Gold and colleagues.
Why it matters
Potential benefit: If successful, this approach could lead to new therapies that slow colorectal cancer and improve outcomes for patients with advanced disease.
How similar studies have gone: Previous preclinical work supports this pathway, but human data are limited, making this an important but early step.
Where this research is happening
-
VA Boston Health Care System
Boston, United States Active
Researchers
- Principal investigator: Gold, Jason Samuel — VA Boston Health Care System
- Study coordinator: Gold, Jason Samuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.