Sex hormones and stroke: a personalized risk map for men and women
Official title: The Role of Sex Hormones in Stroke Risk: A Sex-Specific Integrative Omics Analysis in the NHLBI Trans-Omics for Precision Medicine Cohorts
Funded at University of Vermont & St Agric College · NIH-11387884 · Data updated 2026-11-12
Aims to link sex hormones to stroke risk and build sex-specific prediction tools to prevent stroke for people in diverse populations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $607,962 |
| NIH project number | 5R01HL164485-04 |
| Project ID | NIH-11387884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults of any sex who are at risk for stroke or have a history of stroke, particularly within cohorts represented in TOPMed and external validation cohorts.
✕Less likely to help
Individuals without access to the study cohorts or without risk factors for stroke may see limited direct benefit.
What this research studies
This project uses existing large health datasets to explore how sex hormones influence stroke risk across a lifetime. Researchers will combine genomic, epigenomic, and metabolomic data with clinical information to identify sex-specific targets and build risk scores that can be used in practice. The work involves a collaboration among cerebrovascular and genetic experts to validate findings in an external cohort, with the goal of making stroke prevention more personalized. It’s about translating biological differences into practical tools for reducing stroke burden.
Why it matters
Potential benefit: If successful, the project could lead to more accurate, sex-specific stroke risk predictions and targeted prevention strategies.
How similar studies have gone: Prior work has shown that sex hormones relate to stroke risk, with this project aiming to translate that into predictive models.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Madsen, Tracy — University of Vermont & St Agric College
- Study coordinator: Madsen, Tracy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.