Sex differences in cardiometabolic health and disease
Funded at University of California Los Angeles · NIH-11378200 · Data updated 2026-11-12
A nationwide effort will study why men and women differ in cardiometabolic disease, aiming to improve diagnosis and treatment for both sexes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 20, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,497,077 |
| NIH project number | 5U54HL170326-09 |
| Project ID | NIH-11378200 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with or at risk for fatty heart disease, obesity-related cardiometabolic issues, or sex-specific responses to therapies like statins.
✕Less likely to help
Individuals not currently facing cardiometabolic disease or those without access to related medical care may not directly benefit.
What this research studies
Researchers are using mouse models, patient-derived iPSCs, and existing human data to explore how sex chromosomes, hormones like estrogen, and genetic variation affect cardiometabolic risk. The program includes three research projects and three cores to connect basic biology with human health. Findings could inform more personalized approaches to preventing and treating heart disease that affects men and women differently.
Why it matters
Potential benefit: Could lead to more accurate diagnoses and personalized treatments for cardiometabolic diseases across sexes.
How similar studies have gone: Similar studies have linked sex biology to cardiovascular risk, with growing evidence supporting sex-specific mechanisms and therapies.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Reue, Karen — University of California Los Angeles
- Study coordinator: Reue, Karen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.