Sex chromosomes and beta-cell function in type 2 diabetes
Official title: Sex chromosomes and beta-cell function
Funded at University of Florida · NIH-11625572 · Data updated 2026-11-12
This NIH grant studies how sex differences at the chromosome level affect insulin-producing pancreatic cells in adults with type 2 diabetes, with the goal of guiding personalized treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 9, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $248,999 |
| NIH project number | 4R00DK140067-03 |
| Project ID | NIH-11625572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes, particularly those interested in how sex-specific biology may affect their disease and treatment responses.
✕Less likely to help
People without type 2 diabetes or those not considering sex-specific aspects of islet biology may see limited direct benefit.
What this research studies
The project builds on emerging evidence that men and women may respond differently to diabetes therapies due to sex chromosome genes and sex hormones. It uses human pancreatic slices cultured long-term to model islet biology and to study transcriptional differences between male and female islets. Advanced single-cell and chromatin accessibility techniques will map how sex differences shape beta-cell function and hormone secretion. The work aims to identify novel regulators of islet activity that could lead to sex-specific therapeutic strategies.
Why it matters
Potential benefit: If successful, the research could inform more personalized diabetes treatments based on sex and improve beta-cell preservation strategies.
How similar studies have gone: Preliminary work suggests sex differences influence diabetes mechanisms and therapy responses, with more research needed to translate findings to patients.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Qadir, Mirza Muhammad Fahd — University of Florida
- Study coordinator: Qadir, Mirza Muhammad Fahd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.