SARS-CoV adaptations through a Systems Biology Lens (SYBIL) in humans and animal models
Official title: SARS-CoV adaptations through a Systems Biology Lens (SYBIL)
Funded at Icahn School of Medicine at Mount Sinai · NIH-11533180 · Data updated 2026-11-12
A team at Mount Sinai is studying how SARS-CoV-2 affects the body by mapping host-virus networks and blood biomarkers to identify new targets for therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 20, 2018 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $48,710 |
| NIH project number | 3U19AI135972-09S1 |
| Project ID | NIH-11533180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for SARS-CoV-2 infection or related coronaviruses, plus researchers using patient-derived data and samples,
✕Less likely to help
Healthy individuals or patients without coronavirus infection are unlikely to directly benefit.
What this research studies
This project uses systems biology and omics data to understand how SARS-CoV-2 interacts with human biology and how host responses influence disease severity. Researchers will combine modeling, machine learning, and bioinformatics to pinpoint networks and blood markers tied to infection outcomes. The work builds on prior influenza studies and now extends to SARS-CoV-2 with a focus on host adaptation and early response, including the bat-to-human transition. Findings could reveal new therapeutic targets and guide precision approaches for treating COVID-19 and related coronaviruses.
Why it matters
Potential benefit: If successful, patients could benefit from new therapeutic targets and strategies to improve outcomes in SARS-CoV-2 infection and related coronaviruses.
How similar studies have gone: Prior systems biology work on influenza informed the SARS-CoV-2 shift, with identification of host networks and biomarkers guiding potential interventions.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Garcia-Sastre, Adolfo — Icahn School of Medicine at Mount Sinai
- Study coordinator: Garcia-Sastre, Adolfo
Related research
Other NIH-funded projects on the same topics.
-
Improving Breast Cancer Guideline Adherence in Nigeria
Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.
-
Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
-
Understanding why some brain regions and cells accumulate tau in Alzheimer’s and related diseases
Researchers are studying why certain brain areas and neuron types accumulate tau protein in Alzheimer’s and related conditions, and how this leads to brain changes and symptoms.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
Aging and brain injury connection: learning how late-life TBI relates to Alzheimer’s and related dementias
This grant looks at whether traumatic brain injuries in people 65 and older are linked to Alzheimer’s disease and related dementias, using a large, harmonized set of long-term aging studies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.