Role of AnnexinA2 in HIV-1 and SARS-CoV-2 virus assembly
Official title: Determining the role of AnnexinA2 in HIV-1 and SARS-CoV-2 assembly
Funded at California State University Long Beach · NIH-11384149 · Data updated 2026-11-12
Scientists are studying how a protein called AnnexinA2 helps HIV-1 and SARS-CoV-2 viruses assemble inside cells, which could point to new ways to block these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Long Beach NIH-funded |
| Lab location | 1 site (Long Beach, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $188,125 |
| NIH project number | 5R16AI184450-03 |
| Project ID | NIH-11384149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this basic science grant; however, insights could eventually influence therapies benefiting people with HIV or COVID-19.
✕Less likely to help
This grant does not involve recruiting patients or direct clinical interventions.
What this research studies
This project looks at how HIV-1 and SARS-CoV-2 hijack cell membrane regions called lipid rafts, focusing on AnnexinA2’s role in bringing viral components together. The study will use laboratory experiments to see how AnnexinA2 interacts with viral proteins Nef and Spike and how that affects virus assembly and infectivity. By understanding these mechanisms, researchers hope to identify potential targets for therapies that disrupt viral production. The work is designed to generate foundational knowledge that could inform future drug development against these viruses.
Why it matters
Potential benefit: If successful, the research could reveal new targets to block HIV-1 and SARS-CoV-2 assembly and spread.
How similar studies have gone: Prior studies show that disrupting lipid rafts can reduce infection in both HIV-1 and SARS-CoV-2 models, supporting a potential for meaningful advances.
Where this research is happening
-
California State University Long Beach
Long Beach, United States Active
Researchers
- Principal investigator: Ramirez, Peter William — California State University Long Beach
- Study coordinator: Ramirez, Peter William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.