Role of a long noncoding RNA in normal biology and kidney cancer

Who could benefit from this research

What this research studies

This project explores how CRNDE and related long noncoding RNAs influence cancer biology, using human kidney cancer cells and animal models to uncover their roles in cell growth and disease progression. Researchers will map which RNAs are overexpressed in renal cell carcinoma and test what happens when these RNAs are turned down using CRISPR interference in multiple RCC cell lines. The work aims to uncover mechanisms that could be targeted for new therapies, while also investigating normal physiological roles of CRNDE. Findings could point to new strategies to treat cancer by modulating RNA-level regulation. The grant supports a multi-year effort in cancer biology with translational potential for patient care.”

Why it matters

Where this research is happening

• Ut Southwestern Medical Center
  Dallas, United States Active

Researchers

• Principal investigator: Mendell, Joshua T — Ut Southwestern Medical Center
• Study coordinator: Mendell, Joshua T

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.