Investigating the role of long noncoding RNA in cancer development and progression
The role of long noncoding RNA CRNDE in normal physiology and cancer
This study is looking at how certain molecules called long noncoding RNAs might affect the growth of kidney cancer, specifically renal cell carcinoma, to find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11095749 on NIH RePORTER |
What this research studies
This research focuses on understanding how long noncoding RNAs (lncRNAs) influence the initiation and progression of cancer, particularly renal cell carcinoma (RCC), which is a common and lethal type of kidney cancer. By analyzing RNA sequencing data from RCC patients, the researchers aim to identify specific lncRNAs that are overexpressed in tumors and may play critical roles in cancer cell growth. Using advanced techniques like CRISPR interference, they will explore the functional roles of these lncRNAs in RCC cell lines to uncover potential therapeutic targets. This research could lead to new insights into cancer biology and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with renal cell carcinoma who may benefit from new therapeutic strategies.
Not a fit: Patients with cancers not related to renal cell carcinoma or those without dysregulated lncRNAs may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies targeting lncRNAs, improving treatment outcomes for patients with renal cell carcinoma.
How similar studies have performed: Other research has shown promising results in targeting lncRNAs for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mendell, Joshua T — Ut Southwestern Medical Center
- Study coordinator: Mendell, Joshua T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.