Investigating the role of long noncoding RNA in cancer development and progression

Who could benefit from this research

What this research studies

This research focuses on understanding how long noncoding RNAs (lncRNAs) influence the initiation and progression of cancer, particularly renal cell carcinoma (RCC), which is a common and lethal type of kidney cancer. By analyzing RNA sequencing data from RCC patients, the researchers aim to identify specific lncRNAs that are overexpressed in tumors and may play critical roles in cancer cell growth. Using advanced techniques like CRISPR interference, they will explore the functional roles of these lncRNAs in RCC cell lines to uncover potential therapeutic targets. This research could lead to new insights into cancer biology and treatment options.

Why it matters

Where this research is happening

• Ut Southwestern Medical Center
  Dallas, United States Active

Researchers

• Principal investigator: Mendell, Joshua T — Ut Southwestern Medical Center
• Study coordinator: Mendell, Joshua T

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.