RNA Regulation in Striatal Neurons and Parkinson's Disease
Official title: RNA Regulation in Medium Spiny Neurons of the Striatum in Parkinson's Disease
Funded at Rockefeller University · NIH-11382246 · Data updated 2026-11-12
A clinician-researcher is studying how RNA-binding problems in specific brain cells may contribute to Parkinson's disease symptoms, with potential implications for future treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $220,260 |
| NIH project number | 5K08NS144598-02 |
| Project ID | NIH-11382246 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Parkinson’s disease or related striatal dysfunction may indirectly benefit as the findings could guide future therapies affecting STRIATAL signaling.
✕Less likely to help
People without Parkinson’s disease or related striatal disorders may not directly benefit from these basic science investigations.
What this research studies
This project looks at how RNA-binding proteins in the striatum of the brain affect communication signals that control movement. By focusing on the D1 and D2 neuron subtypes, researchers will examine how abnormal RNA splicing changes the way glutamate and dopamine signals are processed. The study centers on ELAVL3, a protein that influences RNA splicing and is altered in Parkinson’s disease, to see if this leads to dysfunctional signaling in patients. The investigators will use cellular and animal models to explore cell-type specific mechanisms that could eventually point to new therapeutic targets.
Why it matters
Potential benefit: If successful, this work could reveal new targets to restore proper signaling in brain circuits affected by Parkinson’s disease.
How similar studies have gone: Previous work shows that RNA-binding proteins can alter splicing and neuronal signaling, supporting the feasibility of this approach.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Irmady, Krithi — Rockefeller University
- Study coordinator: Irmady, Krithi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.