Ribosome Heterogeneity Lab: Building Tools to Map How Ribosomes Differ Across Cells
Official title: Ion laboratory for the elucidation of macromolecular assembly heterogeneity
Funded at University of Nebraska Lincoln · NIH-11360093 · Data updated 2026-11-12
A lab at the University of Nebraska Lincoln is developing new methods to reveal how ribosomes vary in composition and modifications across different cell types and states.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | July 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $376,995 |
| NIH project number | 5R35GM157097-02 |
| Project ID | NIH-11360093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose cancers or cellular conditions involve ribosome-related translation changes and who could contribute samples for related studies or participate in future trials.
✕Less likely to help
Patients without cancers or conditions linked to ribosome heterogeneity may not benefit directly from this fundamental technology development.
What this research studies
This project aims to create top-down and native mass spectrometry techniques to directly characterize intact ribosomal proteins and their assembly in diverse cell contexts. By improving accurate mass measurement, dissociation, and spectral clarity, the work seeks to map the exact components that form specialized ribosomes. The goal is to understand how these ribosome differences relate to translation control and biology in cancers and related conditions. The research focuses on translating complex molecular data into clearer pictures of ribosome heterogeneity and function.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how ribosome variants influence cancer biology and cellular function, potentially guiding new diagnostic or therapeutic approaches.
How similar studies have gone: Previous work shows that advanced mass spectrometry can reveal protein complexes, but this project seeks to push toward direct, intact ribosome mapping, which is an emerging and promising approach.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Shaw, Jared Bryan — University of Nebraska Lincoln
- Study coordinator: Shaw, Jared Bryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.