reSET for stimulant use in HIV care to boost treatment adherence
Official title: reSET for the Treatment of Stimulant Use in HIV Clinics: Care Optimization Supporting Treatment Adherence (COSTA)
Funded at University of Miami School of Medicine · NIH-11387533 · Data updated 2026-11-12
A 2-arm study will test an all-virtual stimulant use treatment added to HIV care to help people stay engaged in ART.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $994,008 |
| NIH project number | 5R01DA055563-04 |
| Project ID | NIH-11387533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV on ART and a primary diagnosis of stimulant use disorder at participating HIV clinics.
✕Less likely to help
Patients without stimulant use disorder or those not on ART are unlikely to benefit.
What this research studies
This project tests whether a digital therapeutic called reSET, delivered entirely online, can help people with HIV who also struggle with stimulant use stay on antiretroviral therapy. Participants—adults living with HIV and stimulant use disorder—will be randomly assigned to receive either referral to usual outpatient treatment or the all-virtual 12-week stimulant treatment plus standard HIV care. The trial will enroll about 426 patients from HIV clinics in U.S. metro areas with high HIV cases and stimulant use. Researchers will track outcomes such as adherence to ART, stimulant use, and engagement with care over time. If successful, this approach could make it easier for patients to manage both HIV and substance use in real-world settings.
Why it matters
Potential benefit: People could achieve better HIV viral control and overall health by using digital support for stimulant treatment alongside their HIV care.
How similar studies have gone: Previous studies showed reSET helps reduce stimulant use in other settings, but it has not yet been tested in HIV care settings.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Szapocznik, Jose — University of Miami School of Medicine
- Study coordinator: Szapocznik, Jose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.