Receptor-Targeted Nanoparticle PET Tracer for Carotid Plaque Risk in Asymptomatic Stenosis

Who could benefit from this research

What this research studies

This project uses a nanoparticle PET tracer that targets NPRC to image carotid plaques in patients with asymptomatic stenosis. By comparing tracer uptake with plaque features and future stroke risk, researchers aim to improve risk stratification beyond traditional imaging. The study builds on prior human data and two-center collaboration to validate whether imaging can identify individuals who might benefit from carotid intervention. Participants will undergo PET imaging and follow-up to correlate imaging signals with outcomes and plaque biology. The goal is to refine which patients truly need surgery or alternative therapies.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Woodard, Pamela K — Washington University
• Study coordinator: Woodard, Pamela K

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.